民族

汉

籍贯

陕西

最高学位

博士

职称/职务

三级教授

社会兼职

联系

方式

电话

15249093699

邮箱

yaotuanli@sust.edu.cn

学习经历

2005至2006年，美国加州伯克利大学（UC Berkeley）, 博士后

1999至2005年，美国爱荷华州立大学（Iowa State University）, 有机化学博士

1994至1997，北京大学, 硕士

1988至1992年，北京大学, 学士

工作经历

2014.12至今 陕西科技大学化学与化工学院, 教授

2009至2014, 美国堪萨斯大学（KU SCC）, Associated Researcher

2006至2009, 美国Deciphera Pharmaceuticals, Inc., Senior Scientist

1992至1994, 在西安近代化学研究所，助理研究员

研究方向

1. 有机合成方法学：

发展重要杂环化合物的新合成方法，并应用在具有生理活性的天然产物的全合成中。

2. 药物化学：

合成具有生物活性的小分子库，进行新药和仿制药的研发

主要承担项目及成果

承担项目情况：

1. 陕西科技大学高层次人才 （2014年12月-2019年12月）

2. 陕西省自然科学基金面上项目“多样性导向合成原小檗碱类化合物”（2017年1月-2018年12月）

论文发表情况：

35.  Yao, T.^*; Guo, Z.; Liang, X. Qi, L. “Regio- and Stereoselective Electrophilic Cyclization Approach for the Protecting-Group-Free Synthesis of Alkaloids Lennoxamine, Chilenine, Fumaridine, 8-Oxypseudoplamatine and 2-O-Methyloxyfagaronine”  J. Org. Chem. 2018, accepted.

34.  Yao, T.^*; Ren, B.; Zhao, Y. “Highly Selective Synthesis of Dihydrobenzo[d] isoxazoles and Dihydrobenzo[d]oxazoles from Oximes and Arynes via in Situ Generation of Nitrones” Org. Lett. 2017, 19, 3153.

33.  Yao, T.^*; Liu, T.; Zhang, C. “Palladium-catalyzed domino Heck/intermol ecular cross-

coupling: efficient synthesis of 4-alkylated isoquinoline derivatives” Chem. Commun.

2017, 53, 2386.

32.  Yao, T.^*; He, D. “Palladium-Catalyzed Domino Heck/Aryne Carbopalladation/C-H Functionalization:Synthesis of Heterocycle-Fused 9,10-Dihydrophenanthrenes”, Org. Lett. 2017, 19, 842.

31.  Yao, T.^*; Zhang, H.; Zhao, Y. “Synthesis of 9,10-Phenanthrenes via Palladium-Catalyzed Aryne Annulation by o-Halostyrenes and Formal Synthesis of (±)-Tylophorine”, Org. Lett. 2016, 18, 2532.

31. Yao, T.^* “Facile N-arylation of amidines and N,N-disubstituted amidines”, Tetrahedron Lett. 2015, 56, 4623.

30. Yao, T.; Yue, D.; Larock, R. C. “Synthesis of 2,3-disubstituted benzofurans by the palladium-catalyzed coupling of 2-iodoanisoles and terminal alkynes, followed by electrophilic cyclization: 3-iodo-2-phenylbenzofuran”, Org. Synth. 2014, 91, 283.

29. Strouse, J. J.; Ivnitski-Steele, I.; Khawaja, H. M.; Perez, D.; Ricci, J.; Yao, T.; Weiner, W. S.; Schroeder, C. E.; Simpson, D. S.; Maki, B. E. “A selective ATP-binding cassette subfamily g member 2 efflux inhibitor revealed via high-throughput flow cytometry”, J. Biomol. Screen. 2013, 18, 26.

28. Mehta, S.; Yao, T.; Larock, R. C. “Regio- and Stereoselective Synthesis of Cyclic Imidates via Electrophilic Cyclization of 2-(1-Alkynyl)benzamides. A Correction” J. Org. Chem. 2012, 77, 10938.

27. Chen, J.; Young, S. M.; Allen, C.; Seeber, A.; Péli-Gulli, M. P.; Panchaud, N.; Waller, A.; Ursu, O.; Yao, T.; Golden, J. E.; Strouse, J. J.; Carter, M. B.; Kang, H.; Bologa, C. G.; Foutz, T. D.; Edwards, B. S.; Peterson, B. R.; Aubé, J.; Werner-Washburne, M.; Loewith, R. J.; DeVirgilio, C.; Sklar, L. A. “Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry” , ACS Chem Biol. 2012, 10,1021.

26. Chen, Y.; Markina, N. C.; Yao, T.; Larock, R. C. “Synthesis of 2,3-disubstituted indoles via palladium-catalyzed annulation of internal alkynes: 3-methyl-2-(trimethylsilyl)indole”, Org. Synth. 2011, 88, 377.

25. Chan, W. W.; Wise, S. C.; Kaufman, M. D.; Ahn, Y. M.; Ensinger, C. L.; Haack, T.; Hood, M. M.; Jones, J.; Lord, J. W.; Lu, W. P.; Miller, D.; Patt, W. C.; Smith, B. D.; Petillo, P. A.; Rutkoski, T. J.; Telikepalli, H.; Vogeti, L.; Yao, T.; Chun, L.; Clark, R.; Evangelista, P.; Gavrilescu, L. C.; Lazarides, K.; Zaleskas, V. M.; Stewart, L. J.; Van Etten, R. A.; Flynn, D. L. “Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036”, Cancer Cell, 2011, 19, 556.

24. Zhang, X.; Yao, T.; Campo, M. A.; Larock, R. C. “Synthesis of substituted quinolines by the electrophilic cyclization of n-(2-alkynyl)anilines”, Tetrahedron 2010, 66, 1177.

23. Campo, M. A.; Zhang, H.; Yao, T.; Huang, Q.; McCulla, R. D.; Jenks, W. S.; Larock, R. C. “1,4-Palladium Migration in Heck and Suzuki Couplings of o-Iodobiaryls”, J. Am. Chem. Soc. 2007, 129, 6298.

22. Worlikar, S. A.; Kesharwani, T.; Yao, T.; Larock, R. C. “Synthesis of 3,4-disubstituted 2H-benzopyrans through C-C bond formation via electrophilic cyclization”, J. Org. Chem. 2007, 72, 1347.

21. Yao, T.; Hong, A.; Sarpong, R. “Synthesis of Multifunctionalized Furans From Diazoallenes: Novel Rearrangement of 6-Methylene-bicyclo[3.1.0]hexane”, Synthesis 2006, 3605.

20. Yue, D.; Yao, T.; Larock, R. C. “Synthesis of 1,2-Disubstituted 3-Iodoindoles via Palladium Catalyzed Coupling and Electrophilic Cyclization of Terminal Acetylenes”, J. Org. Chem. 2006, 71, 62.

19. Bao, Y.; Lantz, A. W.; Yao, T.; Huang, Q.; Larock, R. C.; Armstrong, D. W. “Enantiomeric separation of furan derivatives and fused polycycles by cyclodextrin-modified micellar capillary electrophoresis”, Electrophoresis 2005, 26, 4164.

18. Yue, D.; Yao, T.; Larock, R. C. “Synthesis of 2,3-Disubstituted Benzo[b]furans by the Palladium-Catalyzed Coupling of o-Iodoanisoles and Terminal Alkynes, Followed by Electrophilic Cyclization”, J. Org. Chem. 2005, 70, 10292.

17. Yao, T.; Yue, D.; Larock, R. C. “Solid-Phase Synthesis of 1,2,3-Trisubstituted Indoles and 2,3-Disubstituted Benzofurans via Iodocyclization”, J. Comb. Chem. 2005, 7, 809.

16. Yao, T.; Yue, D.; Larock, R. C. “An Efficient Synthesis of Coumestans by Iodocyclization and Pd-Catalyzed Intramolecular Lactonization”, J. Org. Chem. 2005, 70, 9985.

15. Yao, T.; Campo, M. A.; Larock, R. C. “Synthesis of Polycyclic Aromatics and Heteroaromatics via Electrophilic Cyclization”, J. Org. Chem. 2005, 70, 3511.

14. Yao, T.; Zhang, X.; Larock, R. C. “Synthesis of Highly Substituted Furans Through a AuCl3-Catalyzed or an Electrophile-Induced Cyclization of 2-(1-Alkynyl)-2-alken-1-ones with Nucleophiles ”, J. Org. Chem. 2005, 70, 7679.

13. Yao, T.; Larock, R. C. “A Regio- and Stereoselective Synthesis of Isoindolin-1-ones via Electrophilic Cyclization ”, J. Org. Chem. 2005, 70, 1432.

12. Zhang, X.; Campo, M. A.; Yao, T.; Larock, R. C. “Synthesis of Substituted Quinolines by Electrophilic Cyclization of N-(2-Alkynyl)anilines”, Org. Lett. 2005, 7, 763.

11. Yao, T.; Larock, R. C. “A Regio- and Stereoselective Synthesis of Isoindolin-1-ones via Electrophilic Cyclization ”, J. Org. Chem. 2005, 70, 1432.

10. Han, X.; Yao, T.; Liu, Y.; Armstrong, D. W.; Larock, R. C. “Separation of Furan Derivatives by Liquid Chromatography Using Cyclodextrin-Based Chiral Stationary Phases”, J. Chromatogr. A, 2005, 1063, 111.

9. Larock, R. C.; Wang, Y.; Dong, X.; Yao, T. “Synthesis of C-5 Substituted Nucleosides via Palladium-catalyzed Coupling of Dienes and Amines”, Tetrahedron, 2005, 61, 11427.

8. Huang, Q.; Campo, M. A.; Yao, T.; Tian, Q.; Larock, R. C. “Synthesis of Fused Polycycles by a 1,4-Palladium Shift”, J. Org. Chem. 2004, 69, 8251.

7. Yao, T.; Zhang, X.; Larock, R. C. “AuCl3-Catalyzed Synthesis of Highly Substituted Furans from 2-(1-Alkynyl)-2-alken-1-ones”, J. Am. Chem. Soc. 2004, 126, 11164.

6. Yao, T.; Campo, M. A.; Larock, R. C. “Synthesis of Polycyclic Aromatic Iodides via ICl-induced Intramolecular Cyclization”, Org. Lett. 2004, 6, 2677.

5. Campo, M. A.; Huang, Q.; Yao, T.; Tian, Q.; Larock, R. C. “1,4-Palladium Migration via C-H Activation, Followed by Arylation: Synthesis of Fused Polycycles”, J. Am. Chem. Soc. 2003, 125, 11506.

4. Yao, T.; Larock, R. C. “Synthesis of Isocoumarins and a-Pyrones via Electrophilic Cyclization”, J. Org. Chem. 2003, 68, 5936.

3. Yao, T.; Larock, R. C. “Synthesis of Isocoumarins and a-Pyrones via Iodocyclization”, Tetrahedron Lett. 2002, 43, 7401.

2. Liu, F.; Li, K.; Chen, W.; Wu, Y.; Yao, T.; Tong, S. “Preconcentration and Separation of Trace Pd(II) and Pt(IV) with Silica Gel Bonded by Aminopropylbenzoylazo-4-(2-pyridylazo)resorcinol”, Chin. J. Chem. 2000, 18, 537.

1. Yao, T; Jin, S.; Wang, C.; Ma, J. “Synthesis of C(10)-(4-Sulfonatophenyl)biliverdin Analogs”, Chem. J. Chin. Univ. 1998, 19, 1078.