民 族

汉族

籍 贯

山东临沂

最高学位

博士

职称/职务

副教授

社会兼职

联系方式

邮箱：wangchao@sust.edu.cn

团队主页：https://chenguang.sust.edu.cn/

实训楼A4002

学习及工作经历

2017.03-现在 陕西科技大学   化学与化工学院   副教授   硕士生导师

2012.09-2017.01 大连理工大学   应用化学专业   博士

2009.09-2012.06 华东理工大学  有机化学专业   硕士

2005.09-2009.06 烟台大学  应用化学专业  本科

主要研究方向

化学生物学/生物有机分析

(1)荧光探针的合成与生物应用

(2)蛋白质荧光标记

承担

的主

要项

目及

成果

作为负责人承担项目：

(1) 国家自然科学基金青年项目，21708023，蛋白靶向的比率型谷胱甘肽荧光探针构建与亚细胞定量检测研究，25万元，2018.01-2020.12，主持

(2) 陕西省自然科学基础研究计划面上项目，2023-JC-YB-110，荧光分子转子-蛋白标签特异性标记体系的构建及其在蛋白相互作用研究中的应用，5万元，2023.01-2024.12，主持

(3) 陕西省自然科学基础研究计划青年项目，2019JQ-061，基于聚集诱导发光分子的蛋白质特异性标记策略设计与生物应用研究，3万元，2019.01-2020.12，主持

(4) 陕西科技大学博士科研启动金，2017GBJ-04，亚细胞蛋白特异性荧光标记与生物分析应用研究，20万元，主持

论文发表：

发表SCI论文三十余篇。

(19) Rong Tang, Chao Wang*, Xuan Zhou, Mengxiang Feng, Zefei Li, Yihan Wang, Guang Chen*. An aggregation induced emission chalcone fluorescent probe with large Stokes shift for biothiols detection. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023, 300: 122870.

(18) Siyue Ma, Yihan Wang, Chao Wang, Linlin Wang, Qing Miao, Yuxia Liu, Yangmin Ma* and Guang Chen*. Accurate monitoring of photoactivation via construction of intramolecular synergistic counteracting mechanism of FRET and IFE. Chemical Communications, 2023, 59, 5599-5602.

(17) Chao Wang*, Tingting Wang, Min Zhao, Fangfang Dai, Zhuolan Niu, Wenqing Zhang, Yangmin Ma*. A simple chalcone molecular rotor for specific  fluorescence imaging of   mitochondrial viscosity changes in living cells.  Dyes and Pigments, 2021, 194: 109593.

(16) G. Fei, S. Ma, C. Wang, T. Chen, Y. Li, Y. Liu, B. Tang*, T.D. James*, G. Chen*. Imaging strategies using cyanine probes and materials for biomedical visualization of live animals. Coordination Chemistry Reviews, 2021, 447, 214134.

(15) Fangfang, Dai; Min, Zhao; Fangzhou, Yang; Tingting, Wang; Chao, Wang*; An ESIPT coupled AIE fluorescent probe for biothiols detection and imaging based on a chalcone fluorophore, Dyes and Pigments, 2020, 183: 108627.

(14) Chao Wang, Minjie Jia, Zhe Bai, Midong Shi, Xiangli Chen, Juan Fan, Fangfang Dai*. The separation of isopropyl alcohol from diisopropyl ether system using glycols: Phase equilibrium and rigorous correlation. Journal of Chemical Thermodynamics, 2020, 150, 106230.

(13) Chao Wang, Xinbo Song, Lingcheng Chen, Yi Xiao*. Specifically and Wash-Free Labeling of SNAP-tag Fused Proteins with a Hybrid Sensor to Monitor Local Micro-Viscosity. Biosensors & Bioelectronics, 2017, 91: 313-320.

(12) Chao Wang¹, Xinbo Song¹, Yi Xiao*. SNAP-tag Based Subcellular Proteins Labeling and Fluorescent Imaging with Naphthalimides. ChemBioChem, 2017, 18(17): 1762-1769.

(11) Chao Wang¹, Xinbo Song¹, Zhuo Han, Xiaoyu Li, Yongping Xu, Yi Xiao*. Monitoring Nitric Oxide in Subcellular Compartments by Hybrid Probe Based on Rhodamine Spirolactam and SNAP-tag. ACS Chemical Biology, 2016, 11(7): 2033-2040.

(10) Fu Yang¹, Chao Wang¹, Lu Wang, Zhiwei Ye, Xinbo Song, Yi Xiao*. Hoechst- Naphthalimide Dyad with Dual Emissions as Specific and Ratiometric Sensor for Nucleus DNA Damage. Chinese Chemical Letters, 2017, 28(10): 2019-2022.（共同第一作者）

(9) Xinbo Song¹, Chao Wang¹, Zhuo Han, Yongping Xu*, Yi Xiao*. Terminal Alkyne Substituted O⁶-benzylguanine for Versatile and Effective Syntheses of Fluorescent Labels to Genetically Encoded SNAP-tags. RSC Advances, 2015, 5(30): 23646-23649.（共同第一作者）

(8) Jianhua Wang¹, Yuzheng Zhao¹, Chao Wang¹, Qian Zhu, Zengmin Du, Aiguo Hu*, Yi Yang*. Organelle-Specific Nitric Oxide Detection in Living Cells via HaloTag Protein Labeling. Plos One, 2015, 10(4): e0123986.（共同第一作者）

(7) Xinbo Song, Ning Li, Chao Wang, Yi Xiao*. Targetable and Fixable Rotor for Quantifying Mitochondrial Viscosity of Living Cells by Fluorescence Lifetime Imaging. Journal of Materials Chemistry B, 2017, 5(2): 360-368.

(6) Xinbo Song, Hui Bian, Chao Wang, Mingyu Hu, Ning Li, Yi Xiao*. Development and Applications of a Near-Infrared Dye-Benzylguanine Conjugate to Specifically Label SNAP-tagged Proteins. Organic & Biomolecular Chemistry, 2017, 15: 8091-8101.

(5) Jingwen Zhang, Chao Wang, Lei Zhang, Huijing Wu, Yi Xiao*, Yufang Xu, Xuhong Qian, Weiping Zhu*. Novel Nonplanar and Rigid Fluorophores with Intensive Emission in Water and the Application in Two-Photon Imaging of Live Cells. RSC Advances, 2016, 6(75): 71624-71627.

(4) Xinfu Zhang, Benlei Wang, Chao Wang, Lingcheng Chen, Yi Xiao* Monitoring Lipid Peroxidation within Foam Cells by Lysosome-Targetable and Ratiometric Probe. Analytical Chemistry, 2015, 87(16): 8292-8300.

(3) Benlei Wang, Xinfu Zhang, Chao Wang, Lingcheng Chen, Yi Xiao*, Yi Pang*. Bipolar and Fixable Probe Targeting Mitochondria to Trace Local Depolarization via Two-Photon Fluorescence Lifetime Imaging. Analyst, 2015, 140(16): 5488-5494.

(2) Xinfu Zhang, Chao Wang, Zhuo Han, Yi Xiao*. A Photostable Near-Infrared Fluorescent Tracker with pH-Independent Specificity to Lysosomes for Long Time and Multicolor Imaging. ACS Applied Materials & Interfaces, 2014, 6(23): 21669-21676.

(1) Xinfu Zhang, Chao Wang, Liji Jin, Zhuo Han, Yi Xiao*. Photostable Bipolar Fluorescent Probe for Video Tracking Plasma Membranes Related Cellular Processes. ACS Applied Materials & Interfaces, 2014, 6(15): 12372-12379.