民族

汉

籍贯

陕西

最高学位

博士

职称/职务

三级教授

邮箱

yaotuanli@sust.edu.cn

学习经历

2005至2006年，博士后

1999至2005年，获得有机化学博士学位

1994至1997年，北京大学, 硕士

1988至1992年，北京大学, 学士

工作经历

2014.12至今 陕西科技大学化学与化工学院, 教授

1992至1994,在西安近代化学研究所，助理研究员

研究方向

1.有机合成方法学：

发展重要杂环化合物的新合成方法，并应用在具有生理活性的天然产物的全合成中。

2.药物化学：

合成具有生物活性的小分子库，进行新药和仿制药的研发

主要承担项目及成果

承担项目情况：

1. 陕西科技大学高层次人才 （2014年12月-2019年12月）

2. 陕西省自然科学基金面上项目“多样性导向合成原小檗碱类化合物”（2017年1月-2018年12月）

论文发表情况：

34. Yao, T.^*;Ren,B.; Zhao, Y. “Highly Selective Synthesis of Dihydrobenzo[d] isoxazoles and Dihydrobenzo[d]oxazoles from Oximes and Arynes via in Situ Generation of Nitrones” Org. Lett.2017,19,3153.

33. Yao, T.^*; Liu,T.; Zhang, C. “Palladium-catalyzed domino Heck/intermol ecular cross-

coupling: efficient synthesis of 4-alkylated isoquinoline derivatives”Chem. Commun.

2017,53, 2386.

32. Yao, T.^*;He,D. “Palladium-Catalyzed Domino Heck/Aryne Carbopalladation/C-H Functionalization:Synthesis of Heterocycle-Fused 9,10-Dihydrophenanthrenes”,Org. Lett.2017,19, 842.

31. Yao, T.^*; Zhang, H.; Zhao, Y. “Synthesis of 9,10-Phenanthrenes via Palladium-Catalyzed Aryne Annulation by o-Halostyrenes and Formal Synthesis of (±)-Tylophorine”,Org. Lett.2016,18, 2532.

31.Yao, T.^* “FacileN-arylation of amidines andN,N-disubstituted amidines”,Tetrahedron Lett.2015,56, 4623.

30.Yao, T.; Yue, D.; Larock, R. C.“Synthesis of 2, 3- disubstituted benzofurans by the palladium- catalyzed coupling of 2- iodoanisoles and terminal alkynes, followed by electrophilic cyclization: 3- iodo- 2- phenylbenzofuran”,Org. Synth.2014, 91,283.

29. Strouse, J. J.; Ivnitski-Steele, I.; Khawaja, H. M.; Perez, D.; Ricci, J.;Yao, T.; Weiner, W. S.; Schroeder, C. E.; Simpson, D. S.; Maki, B. E. “A selective ATP-binding cassette subfamily g member 2 efflux inhibitor revealed via high-throughput flow cytometry”,J. Biomol. Screen.2013,18, 26.

28. Mehta, S.;Yao, T.; Larock, R. C. “Regio- and Stereoselective Synthesis of Cyclic Imidates via Electrophilic Cyclization of 2-(1-Alkynyl)benzamides. A Correction”J. Org. Chem.2012,77, 10938.

27. Chen, J.; Young, S. M.; Allen, C.; Seeber, A.; Péli-Gulli, M. P.; Panchaud, N.; Waller, A.; Ursu, O.;Yao,T.; Golden, J. E.; Strouse, J. J.; Carter, M. B.; Kang, H.; Bologa, C. G.; Foutz, T. D.; Edwards, B. S.; Peterson, B. R.; Aubé, J.; Werner-Washburne, M.; Loewith, R. J.; DeVirgilio, C.; Sklar, L. A. “Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry” ,ACS Chem Biol.2012,10,1021.

26. Chen, Y.; Markina, N. C.;Yao,T.; Larock, R. C. “Synthesis of 2,3-disubstituted indoles via palladium-catalyzed annulation of internal alkynes: 3-methyl-2-(trimethylsilyl)indole”,Org. Synth.2011,88, 377.

25. Chan, W. W.; Wise, S. C.; Kaufman, M. D.; Ahn, Y. M.; Ensinger, C. L.; Haack, T.; Hood, M. M.; Jones, J.; Lord, J. W.; Lu, W. P.; Miller, D.; Patt, W. C.; Smith, B. D.; Petillo, P. A.; Rutkoski, T. J.; Telikepalli, H.; Vogeti, L.;Yao,T.; Chun, L.; Clark, R.; Evangelista, P.; Gavrilescu, L. C.; Lazarides, K.; Zaleskas, V. M.; Stewart, L. J.; Van Etten, R. A.; Flynn, D. L. “Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036”,Cancer Cell,2011,19, 556.

24. Zhang, X.;Yao, T.; Campo, M. A.; Larock, R. C. “Synthesis of substituted quinolines by the electrophilic cyclization of n-(2-alkynyl)anilines”,Tetrahedron2010,66, 1177.

23. Campo, M. A.; Zhang, H.;Yao, T.; Huang, Q.; McCulla, R. D.; Jenks, W. S.; Larock, R. C. “1,4-Palladium Migration in Heck and Suzuki Couplings ofo-Iodobiaryls”,J. Am. Chem. Soc.2007,129, 6298.

22. Worlikar, S. A.; Kesharwani, T.;Yao, T.; Larock, R. C. “Synthesis of 3,4-disubstituted 2H-benzopyrans through C-C bond formation via electrophilic cyclization”,J. Org. Chem.2007,72, 1347.

21.Yao, T.;Hong, A.; Sarpong, R. “Synthesis of Multifunctionalized Furans From Diazoallenes: Novel Rearrangement of 6-Methylene-bicyclo[3.1.0]hexane”,Synthesis2006, 3605.

20. Yue, D.;Yao, T.; Larock, R. C. “Synthesis of 1,2-Disubstituted 3-Iodoindoles via Palladium Catalyzed Coupling and Electrophilic Cyclization of Terminal Acetylenes”,J. Org. Chem. 2006, 71, 62.

19. Bao, Y.; Lantz, A. W.;Yao, T.; Huang, Q.; Larock, R. C.; Armstrong, D. W. “Enantiomeric separation of furan derivatives and fused polycycles by cyclodextrin-modified micellar capillary electrophoresis”,Electrophoresis2005,26, 4164.

18. Yue, D.;Yao, T.; Larock, R. C. “Synthesis of 2,3-Disubstituted Benzo[b]furans by the Palladium-Catalyzed Coupling of o-Iodoanisoles and Terminal Alkynes, Followed by Electrophilic Cyclization”,J. Org. Chem.2005,70, 10292.

17.Yao, T.; Yue, D.; Larock, R. C. “Solid-Phase Synthesis of 1,2,3-Trisubstituted Indoles and 2,3-Disubstituted Benzofurans via Iodocyclization”,J. Comb. Chem.2005,7, 809.

16.Yao, T.; Yue, D.; Larock, R. C. “An Efficient Synthesis of Coumestans by Iodocyclization and Pd-Catalyzed Intramolecular Lactonization”,J. Org. Chem.2005,70, 9985.

15.Yao, T.; Campo, M. A.; Larock, R. C. “Synthesis of Polycyclic Aromatics and Heteroaromatics via Electrophilic Cyclization”,J. Org. Chem.2005,70,3511.

14.Yao, T.; Zhang, X.; Larock, R. C. “Synthesis of Highly Substituted Furans Through a AuCl3-Catalyzed or an Electrophile-Induced Cyclization of 2-(1-Alkynyl)-2-alken-1-ones with Nucleophiles ”,J. Org. Chem.2005,70,7679.

13.Yao, T.; Larock, R. C. “A Regio- and Stereoselective Synthesis of Isoindolin-1-ones via Electrophilic Cyclization ”,J. Org. Chem.2005,70, 1432.

12. Zhang, X.; Campo, M. A.;Yao, T.; Larock, R. C. “Synthesis of Substituted Quinolines by Electrophilic Cyclization ofN-(2-Alkynyl)anilines”,Org. Lett.2005,7, 763.

11.Yao, T.; Larock, R. C. “A Regio- and Stereoselective Synthesis of Isoindolin-1-ones via Electrophilic Cyclization ”,J. Org. Chem.2005,70, 1432.

10. Han, X.;Yao, T.; Liu, Y.; Armstrong, D. W.; Larock, R. C. “Separation of Furan Derivatives by Liquid Chromatography Using Cyclodextrin-Based Chiral Stationary Phases”,J. Chromatogr. A,2005,1063, 111.

9. Larock, R. C.; Wang, Y.; Dong, X.;Yao, T. “Synthesis of C-5 Substituted Nucleosides via Palladium-catalyzed Coupling of Dienes and Amines”,Tetrahedron,2005,61, 11427.

8. Huang, Q.; Campo, M. A.;Yao,T.; Tian, Q.; Larock, R. C. “Synthesis of Fused Polycycles by a 1,4-Palladium Shift”,J. Org. Chem.2004,69,8251.

7.Yao, T.; Zhang, X.; Larock, R. C. “AuCl3-Catalyzed Synthesis of Highly Substituted Furans from 2-(1-Alkynyl)-2-alken-1-ones”,J. Am. Chem. Soc.2004,126, 11164.

6.Yao,T.; Campo, M. A.; Larock, R. C. “Synthesis of Polycyclic Aromatic Iodides via ICl-induced Intramolecular Cyclization”,Org. Lett.2004,6, 2677.

5. Campo, M. A.; Huang, Q.;Yao,T.; Tian, Q.; Larock, R. C. “1,4-Palladium Migration via C-H Activation, Followed by Arylation: Synthesis of Fused Polycycles”,J. Am. Chem. Soc.2003,125, 11506.

4.Yao,T.; Larock, R. C. “Synthesis of Isocoumarins and a-Pyrones via Electrophilic Cyclization”,J. Org. Chem.2003,68, 5936.

3.Yao,T.; Larock, R. C. “Synthesis of Isocoumarins and a-Pyrones via Iodocyclization”,Tetrahedron Lett.2002,43, 7401.

2. Liu, F.; Li, K.; Chen, W.; Wu, Y.;Yao, T.; Tong, S. “Preconcentration and Separation of Trace Pd(II) and Pt(IV) with Silica Gel Bonded by Aminopropylbenzoylazo-4-(2-pyridylazo)resorcinol”,Chin. J. Chem.2000,18, 537.

1.Yao, T; Jin, S.; Wang, C.; Ma, J. “Synthesis of C(10)-(4-Sulfonatophenyl)biliverdin Analogs”,Chem. J. Chin. Univ.1998,19, 1078.